| NCT06369285 | A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer | RECRUITING | PHASE2 | 2024-11-19 | 2028-12-31 | 2027-06-30 |
| NCT06095505 | A Study of Alisertib in Patients With Extensive Stage Small Cell Lung Cancer | RECRUITING | PHASE2 | 2024-02-08 | 2027-10-31 | 2027-04-30 |
| NCT04366713 | A Study to Characterize Colon Pathology in Patients With HER2 Amplified Breast Cancer Treated With Neratinib | COMPLETED | PHASE2 | 2020-06-30 | 2021-12-28 | 2021-12-28 |
| NCT02400476 | An Open-Label Study to Characterize the Incidence and Severity of Diarrhea in Patients With Early-Stage HER2+ Breast Cancer Treated With Neratinib and Loperamide | COMPLETED | PHASE2 | 2015-02 | 2021-04-22 | 2021-04-22 |
| NCT02334501 | Open-label PK Study to Evaluate Lansoprazole and Neratinib in Healthy Subjects | COMPLETED | PHASE1 | 2014-08 | 2014-10 | 2014-10 |
| NCT01953926 | Basket Study of Neratinib in Participants With Solid Tumors Harboring Somatic HER2 or EGFR Exon 18 Mutations | TERMINATED | PHASE2 | 2013-09-30 | 2023-01-02 | 2023-01-02 |
| NCT01827267 | Neratinib With and Without Temsirolimus for Patients With HER2 Activating Mutations in Non-Small Cell Lung Cancer | COMPLETED | PHASE2 | 2013-07-01 | 2017-10-06 | 2016-09-20 |
| NCT01808573 | A Study of Neratinib Plus Capecitabine Versus Lapatinib Plus Capecitabine in Patients With HER2+ Metastatic Breast Cancer Who Have Received Two or More Prior HER2 Directed Regimens in the Metastatic Setting | COMPLETED | PHASE3 | 2013-03-29 | 2019-12-09 | 2018-09-28 |
| NCT00932464 | Study Evaluating The Effect Of A High-Fat Meal On The Pharmacokinetics Of Neratinib | WITHDRAWN | PHASE1 | 2012-08 | 2012-08 | 2012-08 |
| NCT01128842 | A Study Of Neratinib (HKI-272) And Capecitabine In Japanese With Solid Tumor | COMPLETED | PHASE1 | 2010-04 | 2011-03 | 2011-03 |
| NCT01111825 | Temsirolimus Plus Neratinib for Patients With Metastatic HER2-Amplified or Triple Negative Breast Cancer | COMPLETED | PHASE1, PHASE2 | 2010-04 | 2016-07 | 2016-07 |
| NCT00915018 | Study Evaluating Neratinib Plus Paclitaxel VS Trastuzumab Plus Paclitaxel In ErbB-2 Positive Advanced Breast Cancer | COMPLETED | PHASE2 | 2009-08-21 | 2018-06-28 | 2013-08 |
| NCT00878709 | Study Evaluating The Effects Of Neratinib After Adjuvant Trastuzumab In Women With Early Stage Breast Cancer | COMPLETED | PHASE3 | 2009-07-09 | 2019-10-04 | 2014-08-21 |
| NCT00958724 | Study Evaluating Neratinib In Combination With Vinorelbine In Subjects With Advanced Or Metastatic Solid Tumors | COMPLETED | PHASE1 | 2009-07 | 2010-04 | 2010-04 |
| NCT00838539 | Study Evaluating Neratinib In Combination With Temsirolimus In Subjects With Solid Tumors | COMPLETED | PHASE1 | 2009-04 | 2013-12 | 2011-06 |
| NCT00781430 | Study Evaluating The PK And Safety Of Neratinib In Healthy Subjects And Subjects With Chronic Liver Disease | COMPLETED | PHASE1 | 2009-04 | 2010-02 | 2010-02 |
| NCT00860223 | Study Evaluating The Potential Effect Of Multiple Doses Of Neratinib On The Pharmacokinetics Of A Single Dose Of Digoxin | COMPLETED | PHASE1 | 2009-04 | 2009-04 | 2009-04 |
| NCT00864487 | Study Evaluating The Potential Effect Of Rifampin On The Pharmacokinetics Of Neratinib | COMPLETED | PHASE1 | 2009-04 | 2009-05 | 2009-05 |
| NCT00777101 | Study Evaluating Neratinib Versus Lapatinib Plus Capecitabine For ErbB2 Positive Advanced Breast Cancer | COMPLETED | PHASE2 | 2009-02-04 | 2018-06-03 | 2011-03 |
| NCT00814060 | Study Evaluating TwoTablet Formulations of Neratinib (HKI-272) | COMPLETED | PHASE1 | 2009-01 | 2009-03 | 2009-03 |
| NCT00741260 | Study Evaluating The Combination Of Neratinib And Capecitabine In Solid Tumors And Breast Cancer | COMPLETED | PHASE1, PHASE2 | 2008-12-09 | 2018-06 | 2010-11 |
| NCT00768469 | Study Evaluating Safety And Tolerability, Solid Tumor | COMPLETED | PHASE1 | 2008-10 | 2011-01 | 2011-01 |
| NCT00757809 | Study Evaluating The Tolerability Of Multiple Doses Of HKI-272 | COMPLETED | PHASE1 | 2008-10 | 2008-10 | 2008-10 |
| NCT00708903 | Study to Examine the Effect of HKI-272 on Rhythms of the Heart (Cardiac Repolarization) | COMPLETED | PHASE1 | 2008-05 | 2008-07 | 2008-07 |
| NCT00706030 | Study Evaluating Neratinib (HKI-272) In Combination With Vinorelbine In Subjects With Solid Tumors And Metastatic Breast Cancer | COMPLETED | PHASE1, PHASE2 | 2008-04-29 | 2018-06-07 | 2009-10 |
| NCT00550212 | Study Evaluating Oral Administrations of HKI-272 in Healthy Male Subjects | COMPLETED | PHASE1 | 2008-03 | 2008-04 | 2008-04 |
| NCT00445458 | A Phase 1/2 Study of HKI-272 (Neratinib) in Combination With Paclitaxel (Taxol) in Subjects With Solid Tumors and Breast Cancer | COMPLETED | PHASE1, PHASE2 | 2007-09-11 | 2018-02-07 | 2011-05 |
| NCT00498745 | Study Comparing 2 New Formulations of HKI-272 in Healthy Adult Subjects | COMPLETED | PHASE1 | 2007-07 | 2007-09 | |
| NCT00398567 | A Phase 1/2 Study Of HKI-272 (Neratinib) in Combination With Trastuzumab (Herceptin) In Subjects With Advanced Breast Cancer | COMPLETED | PHASE1, PHASE2 | 2007-04-04 | 2018-03-02 | 2009-07-31 |
| NCT00397046 | A Study Of The Safety And Tolerability Of HKI-272 Administered Orally To Japanese Subjects With Advanced Solid Tumors | COMPLETED | PHASE1 | 2006-11 | 2009-03 | 2009-03 |
| NCT00380328 | HKI-272 Ketoconazole Drug Interaction Study | COMPLETED | PHASE1 | 2006-10 | 2006-11 | |
| NCT00300781 | Study Evaluating HKI-272 (Neratinib) In Subjects With Advanced Breast Cancer | COMPLETED | PHASE2 | 2006-08-04 | 2018-01-30 | 2008-04 |
| NCT00366600 | Study Evaluating HKI-272 Administered to Healthy Subjects | COMPLETED | PHASE1 | 2006-07 | 2006-12 | 2006-12 |
| NCT00266877 | Study Evaluating the Safety Of HKI-272 (Neratinib) In Subjects With Advanced Non-Small Cell Lung Cancer | COMPLETED | PHASE2 | 2005-12 | 2009-01 | 2009-01 |
| NCT00146172 | Study Evaluating HKI-272 in Tumors | COMPLETED | PHASE1 | 2003-11 | 2007-01 | 2007-01 |