Clinical Trials - MRNA

NCT IDTitleStatusPhasesStart DateCompletion DatePrimary Completion Date
NCT07116616A Study of mRNA-2808 in Participants With Relapsed or Refractory Multiple MyelomaNOT_YET_RECRUITINGPHASE1, PHASE22025-10-152032-06-172030-06-17
NCT07117487A Study of mRNA-1345 Following a Primary Dose of a Licensed Protein Subunit Respiratory Syncytial Virus (RSV) Vaccine in Adult Participants ≥60 Years of AgeRECRUITINGPHASE32025-08-052026-04-152026-04-15
NCT07089706A Study to Evaluate the Immunogenicity and Safety of mRNA-1283 COVID-19 Variant-containing FormulationsACTIVE_NOT_RECRUITINGPHASE42025-07-212025-09-112025-09-11
NCT06735248A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 YearsRECRUITINGPHASE22025-04-162029-01-082029-01-08
NCT06880549A Study of mRNA-4106 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Solid TumorsRECRUITINGPHASE12025-03-252029-01-102029-01-10
NCT06864143A Study to Investigate the Immunogenicity, Reactogenicity, and Safety of mRNA-1083 (Influenza and COVID-19) Vaccine in Adults ≥18 to <65 Years of AgeRECRUITINGPHASE22025-03-072025-10-062025-10-06
NCT06694389Study to Investigate the Immunogenicity, Reactogenicity, and Safety of mRNA-1083 Vaccine (SARS-CoV-2 [COVID-19] and Influenza) in Adults ≥50 Years of AgeACTIVE_NOT_RECRUITINGPHASE32024-11-182025-12-102025-12-10
NCT06655870A Study to Investigate Safety and Tolerability of mRNA-0184 Administered Subcutaneously in Healthy ParticipantsRECRUITINGPHASE12024-10-312025-12-202025-12-20
NCT06634797A Study to Investigate Cardiac Troponin Levels After mRNA-1273.712 Vaccine in Participants 12 Through 30 Years of AgeCOMPLETEDPHASE42024-10-082025-01-202025-01-20
NCT06592794A Study to Investigate the Safety and Efficacy of mRNA-1403 in Participants ≥18 Years of Age for the Prevention of Acute GastroenteritisACTIVE_NOT_RECRUITINGPHASE32024-09-242027-05-312027-05-31
NCT06602024A Study of mRNA-1010 Compared With a Licensed Influenza Vaccine in Adults ≥50 Years of AgeCOMPLETEDPHASE32024-09-162025-08-212025-08-21
NCT06585241A Study to Investigate the Immunogenicity of mRNA COVID-19 Variant-containing Vaccine Formulations in Adults to Prevent COVID-19ACTIVE_NOT_RECRUITINGPHASE42024-09-092025-10-292025-10-29
NCT06508320A Clinical Study to Investigate the Safety and Immunogenicity in Relation to Product Attributes of mRNA-1083 (Severe Acute Respiratory Syndrome Coronavirus 2 [SARS-CoV-2] and Influenza Vaccine)ACTIVE_NOT_RECRUITINGPHASE22024-07-152025-09-172025-09-17
NCT06354998A Study of an Investigational mRNA-1273.815 COVID-19 Vaccine in Previously Vaccinated AdultsCOMPLETEDPHASE32024-04-082024-05-102024-05-10
NCT06147856A Dose-finding Study to Evaluate mRNA-3210 in Participants With PhenylketonuriaWITHDRAWNPHASE1, PHASE22024-03-292027-08-052026-08-10
NCT06243770Study to Investigate Safety and Tolerability of mRNA-0184 Administered Under Different Infusion Conditions in Healthy ParticipantsCOMPLETEDPHASE12024-02-162025-06-122025-06-12
NCT06133010A Study of mRNA-1647 Cytomegalovirus Vaccine in Liver Transplant Candidates and RecipientsWITHDRAWNPHASE22024-02-082027-12-142027-02-14
NCT06143046A Study of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus in Pregnant Women and in Infants Born to Vaccinated MothersACTIVE_NOT_RECRUITINGPHASE22023-11-152026-02-182026-02-18
NCT06097299A Study of mRNA-1345, an mRNA Vaccine Targeting Respiratory Syncytial Virus, in Children 2 to <18 Years of Age at High Risk of Respiratory Syncytial VirusCOMPLETEDPHASE22023-10-242025-06-272025-06-27
NCT06097273A Study of mRNA-1083 (SARS-CoV-2 and Influenza) Vaccine in Healthy Adult Participants, ≥50 Years of AgeCOMPLETEDPHASE32023-10-192024-05-282024-05-28
NCT06067230A Study to Investigate the Immunogenicity and Safety of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus (RSV) in High-risk AdultsACTIVE_NOT_RECRUITINGPHASE32023-10-062026-07-302026-07-30
NCT06060457A Study to Evaluate the Safety and Immune Response of mRNA-1345, a Vaccine Targeting Respiratory Syncytial Virus (RSV), When Co-administered With a Fluzone HD, in Adults ≥65 Years of AgeCOMPLETEDPHASE32023-09-252024-06-072024-06-07
NCT06033261A Study of mRNA-1608, a Herpes Simplex Virus -2 (HSV-2) Therapeutic Candidate Vaccine, in Healthy Adults 18 to 55 Years of Age With Recurrent HSV-2 Genital HerpesCOMPLETEDPHASE1, PHASE22023-09-062025-04-252025-04-25
NCT05992935Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1403 and mRNA-1405 to Prevent Norovirus Acute Gastroenteritis in Healthy Adults 18 to 80 Years of AgeACTIVE_NOT_RECRUITINGPHASE1, PHASE22023-08-252026-11-202026-04-14
NCT05995275A Study to Investigate The Safety, Tolerability, And Immune Response of a Range of Doses of mRNA-1769 Compared With Placebo in Healthy Participants From ≥18 Years of Age to <50 Years of AgeCOMPLETEDPHASE1, PHASE22023-08-152025-07-082025-07-08
NCT05918250mRNA-2736 for Participants With Relapsed or Refractory Multiple Myeloma (RRMM)WITHDRAWNPHASE12023-08-152026-05-272026-05-27
NCT05975099A Study to Evaluate the Safety and Immunogenicity of mRNA-1975 and mRNA-1982 Against Lyme Disease in Participants 18 Through 70 Years of AgeCOMPLETEDPHASE1, PHASE22023-07-262025-05-302025-05-30
NCT05972174A Study of mRNA-1018 Pandemic Influenza Candidate Vaccines in Healthy AdultsCOMPLETEDPHASE1, PHASE22023-07-102024-07-162024-07-16
NCT05868382Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA Vaccine Candidate Variations in Healthy AdultsCOMPLETEDPHASE22023-05-152023-12-192023-12-19
NCT05827978Study of mRNA-1010 Seasonal Influenza Vaccine in AdultsCOMPLETEDPHASE32023-04-172024-06-242024-06-24
NCT05827926A Study of mRNA-based Influenza and SARS-CoV-2 (COVID-19) Multi-component Vaccines in Healthy AdultsCOMPLETEDPHASE1, PHASE22023-04-142024-12-032024-12-03
NCT05831111A Study of an Epstein-Barr Virus (EBV) Candidate Vaccine, mRNA-1195, in 18- to 55-Year-Old Healthy ParticipantsACTIVE_NOT_RECRUITINGPHASE12023-04-052026-10-072026-10-07
NCT05683457A Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Allogenic Hematopoietic Cell Transplantation (HCT) Participants.RECRUITINGPHASE22023-04-052026-08-012026-08-01
NCT05815498A Study of mRNA-1283 Injection Compared With mRNA-1273 Injection in Participants ≥12 Years of Age to Prevent COVID-19COMPLETEDPHASE32023-03-282025-04-122025-04-12
NCT05827068A Study of mRNA-1011.1, mRNA-1011.2, and mRNA-1012.1 Candidate Seasonal Influenza Vaccines in Healthy AdultsCOMPLETEDPHASE1, PHASE22023-03-272023-11-202023-11-20
NCT05743881A Safety, Tolerability, and Immunogenicity Study of mRNA-1345 and mRNA-1365 in Participants Aged 5 Months to <24 MonthsACTIVE_NOT_RECRUITINGPHASE12023-02-152026-09-302026-08-31
NCT05701800A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1468 in Healthy Adults ≥50 Years of AgeACTIVE_NOT_RECRUITINGPHASE1, PHASE22023-01-232026-06-302026-06-30
NCT05659264A Study to Evaluate the Safety of mRNA-0184 in Participants With Heart FailureCOMPLETEDPHASE12022-12-052024-12-172024-12-17
NCT05575492A Study of mRNA-1647 Cytomegalovirus Vaccine in Healthy Participants 9 to 15 Years of Age and Participants 16 to 25 Years of AgeACTIVE_NOT_RECRUITINGPHASE1, PHASE22022-11-072027-01-152027-01-15
NCT05606965A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1010 in Healthy AdultsRECRUITINGPHASE22022-11-022025-11-112025-11-11
NCT05585632A Safety, Reactogenicity, and Immunogenicity Study of mRNA-1045 (Influenza and Respiratory Syncytial Virus [RSV]) or mRNA-1230 (Influenza, RSV, and Severe Acute Respiratory Syndrome Coronavirus 2 [SARS-CoV-2]) Vaccine in Adults 50 to 75 Years OldCOMPLETEDPHASE12022-10-142024-02-282024-02-28
NCT05584202Study to Evaluate the Safety, Reactogenicity, and Effectiveness of mRNA-1273.214 SARS-CoV-2 (COVID-19) Vaccine in InfantsTERMINATEDPHASE22022-09-302024-11-152024-11-15
NCT05566639A Study of mRNA-1010 Seasonal Influenza Vaccine in Adults 50 Years Old and OlderCOMPLETEDPHASE32022-09-142024-01-052024-01-05
NCT05533697Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid TumorsRECRUITINGPHASE1, PHASE22022-09-012032-02-182032-02-18
NCT05436834A Study to Evaluate the Safety and Immunogenicity of the mRNA COVID-19 Vaccines in Healthy Children Between 6 Months to Less Than 6 Years of AgeRECRUITINGPHASE32022-06-212025-10-272025-10-27
NCT05415462A Study of mRNA-1010 Seasonal Influenza Vaccine in AdultsCOMPLETEDPHASE32022-06-062023-09-042023-09-04
NCT05095727A Study of mRNA-3745 in Adult and Pediatric Participants With Glycogen Storage Disease Type 1a (GSD1a)RECRUITINGPHASE1, PHASE22022-06-012028-12-262026-05-26
NCT05397223A Study of Modified mRNA Vaccines in Healthy AdultsACTIVE_NOT_RECRUITINGPHASE12022-05-242026-02-212026-02-21
NCT05375838A Safety, Reactogenicity, and Immunogenicity Study of mRNA-1073 (COVID-19/Influenza) Vaccine in Adults 18 to 75 Years OldCOMPLETEDPHASE1, PHASE22022-05-132022-12-292022-12-29
NCT05333289A Study of mRNA-1020 and mRNA-1030 Seasonal Influenza Vaccines in Healthy AdultsCOMPLETEDPHASE1, PHASE22022-04-062022-11-222022-11-22
NCT05330975A Study of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus (RSV) in Adults ≥50 Years of AgeCOMPLETEDPHASE32022-04-012024-11-082024-11-08
NCT05295433An Extension Study to Evaluate the Long-Term Safety and Clinical Activity of mRNA-3705 in Participants Previously Enrolled in Other Clinical Studies of mRNA-3705RECRUITINGPHASE1, PHASE22022-03-082034-04-022032-04-01
NCT05249829A Study to Evaluate the Immunogenicity and Safety of Omicron Variant Vaccines in Comparison With mRNA-1273 Booster Vaccine for COVID-19COMPLETEDPHASE2, PHASE32022-02-162023-06-232023-06-23
NCT05164094A Study of an Epstein-Barr Virus (EBV) Candidate Vaccine, mRNA-1189, in 10- to 30-Year-Old Healthy Adolescents and AdultsACTIVE_NOT_RECRUITINGPHASE1, PHASE22021-12-282026-10-052026-10-05
NCT05137236A Study to Evaluate the Immunogenicity and Safety of mRNA-1283 COVID-19 Vaccine BoostersCOMPLETEDPHASE22021-12-062023-03-232023-03-23
NCT05127434A Study to Evaluate the Safety and Efficacy of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus (RSV) in Adults ≥60 Years of AgeCOMPLETEDPHASE2, PHASE32021-11-172025-07-282025-07-28
NCT05130437A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 StudyRECRUITINGPHASE1, PHASE22021-11-092031-12-042029-12-04
NCT05105048A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of Cytomegalovirus (CMV) Vaccine mRNA-1647COMPLETEDPHASE12021-11-082023-08-102023-08-10
NCT05085366A Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Healthy Participants 16 to 40 Years of AgeACTIVE_NOT_RECRUITINGPHASE32021-10-262028-04-302026-04-30
NCT04899310A Study to Assess Safety, Pharmacokinetics, and Pharmacodynamics of mRNA-3705 in Participants With Isolated Methylmalonic AcidemiaRECRUITINGPHASE1, PHASE22021-08-062028-08-012026-08-01
NCT04916431A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of mRNA-6231 in Healthy AdultsCOMPLETEDPHASE12021-07-282022-08-022022-08-02
NCT04956575A Study of mRNA-1010 Seasonal Influenza Vaccine in Healthy AdultsCOMPLETEDPHASE1, PHASE22021-07-062022-09-272022-09-27
NCT04975893A Long-Term Extension Study to Evaluate the Immunogenicity and Safety of Cytomegalovirus (CMV) mRNA-1647 VaccineENROLLING_BY_INVITATIONPHASE22021-06-182026-12-302026-12-30
NCT04917861A Study of Zika Vaccine mRNA-1893 in Adult Participants Living in Endemic and Non-Endemic Flavivirus AreasCOMPLETEDPHASE22021-06-072024-07-262024-07-26
NCT04927065A Study to Evaluate the Immunogenicity and Safety of mRNA Vaccine Boosters for SARS-CoV-2 (COVID-19) VariantsCOMPLETEDPHASE2, PHASE32021-05-282023-11-172023-11-17
NCT04860297A Study to Evaluate Safety and Immunogenicity of mRNA-1273 Vaccine to Prevent COVID-19 in Adult Organ Transplant Recipients and in Healthy Adult ParticipantsCOMPLETEDPHASE32021-04-162023-05-222023-05-22
NCT04159103Open-Label Study of mRNA-3927 in Participants With Propionic AcidemiaRECRUITINGPHASE1, PHASE22021-04-152026-01-312026-01-31
NCT04796896A Study to Evaluate Safety and Effectiveness of mRNA-1273 COVID-19 Vaccine in Healthy Children Between 6 Months of Age and Less Than 12 Years of AgeCOMPLETEDPHASE2, PHASE32021-03-152024-03-152024-03-15
NCT04813796A Study to Evaluate Safety, Reactogenicity, and Immunogenicity of mRNA-1283 and mRNA-1273 Vaccines in Healthy Adults Between 18 Years and 55 Years of Age to Prevent COVID-19COMPLETEDPHASE12021-03-112023-07-252023-07-25
NCT04649151A Study to Evaluate the Safety, Reactogenicity, and Effectiveness of mRNA-1273 Vaccine in Adolescents 12 to <18 Years Old to Prevent COVID-19COMPLETEDPHASE2, PHASE32020-12-092024-06-142024-06-14
NCT04528719A Dose Escalation Study to Evaluate Safety, Reactogenicity, and Immunogenicity of mRNA-1345 in Healthy Adults and in Children Who Are Respiratory Syncytial Virus (RSV)-SeropositiveCOMPLETEDPHASE12020-09-302024-07-182024-07-18
NCT04470427A Study to Evaluate Efficacy, Safety, and Immunogenicity of mRNA-1273 Vaccine in Adults Aged 18 Years and Older to Prevent COVID-19COMPLETEDPHASE32020-07-272022-12-292022-12-29
NCT04405076Dose-Confirmation Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1273 COVID-19 Vaccine in Adults Aged 18 Years and OlderCOMPLETEDPHASE22020-05-292021-10-282021-10-28
NCT04232280Dose-Finding Trial to Evaluate the Safety and Immunogenicity of Cytomegalovirus (CMV) Vaccine mRNA-1647 in Healthy AdultsCOMPLETEDPHASE22020-01-092023-01-042023-01-04
NCT04144348Safety and Immunogenicity of mRNA-1653, a Combined Human Metapneumovirus (hMPV) and Parainfluenza Virus Type 3 (PIV3) Vaccine, in Healthy Adults, and Children 12 to 59 Months of Age With Serologic Evidence of Prior ExposureCOMPLETEDPHASE12019-11-042022-12-202022-12-20
NCT04064905Safety, Tolerability, and Immunogenicity of Zika Vaccine mRNA-1893 in Healthy Flavivirus Seropositive and Seronegative AdultsCOMPLETEDPHASE12019-07-302021-03-222021-03-22
NCT03897881An Efficacy Study of Adjuvant Treatment With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab in Participants With High-Risk Melanoma (KEYNOTE-942)RECRUITINGPHASE22019-07-182029-09-092029-09-09
NCT03810690Open Label Study of mRNA-3704 in Patients With Isolated Methylmalonic AcidemiaWITHDRAWNPHASE1, PHASE22019-05-282020-08-182020-08-18
NCT03829384Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of mRNA-1944 in Healthy AdultsCOMPLETEDPHASE12019-01-222021-06-072021-06-07
NCT03739931Dose Escalation Study of mRNA-2752 for Intratumoral Injection to Participants in Advanced MalignanciesCOMPLETEDPHASE12018-11-272025-08-012025-08-01
NCT03392389Safety, Reactogenicity, and Immunogenicity of mRNA-1653 in Healthy AdultsCOMPLETEDPHASE12017-12-042019-07-292019-07-29
NCT03382405Safety, Reactogenicity, and Immunogenicity of Cytomegalovirus Vaccines mRNA-1647 and mRNA-1443 in Healthy AdultsCOMPLETEDPHASE12017-11-132020-10-282020-10-28
NCT03323398Dose Escalation and Efficacy Study of mRNA-2416 for Intratumoral Injection Alone and in Combination With Durvalumab for Participants With Advanced MalignanciesTERMINATEDPHASE1, PHASE22017-08-152021-08-182021-08-18
NCT03313778Safety, Tolerability, and Immunogenicity of mRNA-4157 Alone and in Combination in Participants With Solid TumorsRECRUITINGPHASE12017-08-142027-08-012027-08-01
NCT03325075Safety, Tolerability, and Immunogenicity of VAL-181388 in Healthy ParticipantsCOMPLETEDPHASE12017-07-192019-03-192019-03-19
NCT03014089Safety, Tolerability, and Immunogenicity of mRNA-1325 in Healthy Adult SubjectsCOMPLETEDPHASE12016-12-212019-07-312019-07-31
NCT03345043Safety, Tolerability, and Immunogenicity of VAL-339851 in Healthy Adult SubjectsCOMPLETEDPHASE12016-05-112018-08-132018-08-13
NCT03076385Safety, Tolerability, and Immunogenicity of VAL-506440 in Healthy Adult SubjectsCOMPLETEDPHASE12015-122018-102018-10