| NCT06481891 | A Study to Evaluate the Efficacy and Safety of Sotagliflozin in Symptomatic Obstructive and Non-obstructive Hypertrophic Cardiomyopathy | RECRUITING | PHASE3 | 2024-09-24 | 2026-08 | 2026-07 |
| NCT06203002 | A Dose-ranging Study in Patients With Diabetic Peripheral Neuropathic Pain (DPNP) | COMPLETED | PHASE2 | 2023-11-29 | 2025-02-24 | 2025-01-14 |
| NCT04662281 | Efficacy and Safety of LX9211 in Participants With Postherpetic Neuralgia | COMPLETED | PHASE2 | 2020-12-29 | 2022-12-21 | 2022-11-18 |
| NCT04455633 | Efficacy, Safety, and PK of LX9211 in Participants With Diabetic Peripheral Neuropathic Pain | COMPLETED | PHASE2 | 2020-09-03 | 2022-06-28 | 2022-05-23 |
| NCT03521934 | Effect of Sotagliflozin on Cardiovascular Events in Participants With Type 2 Diabetes Post Worsening Heart Failure (SOLOIST-WHF Trial) | TERMINATED | PHASE3 | 2018-06-15 | 2020-06-05 | 2020-06-05 |
| NCT03386344 | Efficacy and Bone Safety of Sotagliflozin 400 and 200 mg Versus Placebo in Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control | TERMINATED | PHASE3 | 2018-02-19 | 2020-05-30 | 2019-05-22 |
| NCT03315143 | Effect of Sotagliflozin on Cardiovascular and Renal Events in Participants With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk | TERMINATED | PHASE3 | 2017-12-19 | 2020-07-08 | 2020-07-08 |
| NCT03292653 | Safety, Tolerability and Pharmacodynamic Activity of Sotagliflozin in Hemodynamically Stable Participants With Worsening Heart Failure | TERMINATED | PHASE2 | 2017-12-04 | 2019-08-17 | 2019-08-17 |
| NCT03332771 | Efficacy and Safety of Sotagliflozin Versus Glimepiride and Placebo in Participants With Type 2 Diabetes Mellitus That Are Taking Metformin Monotherapy | COMPLETED | PHASE3 | 2017-12-01 | 2019-09-06 | 2019-08-06 |
| NCT03423446 | Study to Evaluate the Pharmacokinetics of Telotristat Ethyl in Subjects With Severe Hepatic Impairment | COMPLETED | PHASE1 | 2017-11-28 | 2018-06-15 | 2018-06-15 |
| NCT03351478 | Efficacy and Safety of Sotagliflozin Versus Placebo and Empagliflozin in Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking a DPP4 Inhibitor Alone or With Metformin | COMPLETED | PHASE3 | 2017-11-27 | 2019-05-16 | 2019-05-16 |
| NCT03302845 | A Phase 1 Study to Evaluate the Effects of Omeprazole and Famotidine on the Absorption of Telotristat Ethyl in Healthy Subjects | COMPLETED | PHASE1 | 2017-09-21 | 2017-11-07 | 2017-10-23 |
| NCT03285594 | Efficacy and Safety of Sotagliflozin Versus Placebo in Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking Insulin Alone or With Other Oral Antidiabetic Agents | COMPLETED | PHASE3 | 2017-09-15 | 2019-09-27 | 2019-09-17 |
| NCT03242018 | A Study to Evaluate Safety and Effects of Sotagliflozin 400 and 200 mg on Glucose Control in Participants With Type 2 Diabetes, Severe Impairment of Kidney Function and Inadequate Blood Sugar Control | COMPLETED | PHASE3 | 2017-08-16 | 2019-12-11 | 2019-05-16 |
| NCT03242252 | Safety and Efficacy Study of Sotagliflozin on Glucose Control in Participants With Type 2 Diabetes, Moderate Impairment of Kidney Function, and Inadequate Blood Sugar Control | COMPLETED | PHASE3 | 2017-08-16 | 2019-10-25 | 2019-03-25 |
| NCT03066830 | Efficacy and Safety of Sotagliflozin Versus Placebo in Participants With Type 2 Diabetes Mellitus on Background of Sulfonylurea Alone or With Metformin | COMPLETED | PHASE3 | 2017-02-24 | 2019-04-30 | 2019-04-17 |
| NCT02926937 | Efficacy and Safety of Sotagliflozin Versus Placebo in Patients With Type 2 Diabetes Mellitus Not Currently Treated With Antidiabetic Therapy | COMPLETED | PHASE3 | 2016-11-11 | 2019-05-17 | 2019-04-22 |
| NCT02926950 | Efficacy and Safety of Sotagliflozin Versus Placebo in Patients With Type 2 Diabetes Mellitus on Background of Metformin | COMPLETED | PHASE3 | 2016-11 | 2019-03-22 | 2019-02-26 |
| NCT02647918 | Study to Evaluate Sotagliflozin in Subjects With Varying Degrees of Renal Function | COMPLETED | PHASE1 | 2015-12 | 2017-09 | 2017-09 |
| NCT02531035 | A Phase 3 Study to Evaluate the Safety of Sotagliflozin in Patients With Type 1 Diabetes Who Have Inadequate Glycemic Control With Insulin Therapy Alone | COMPLETED | PHASE3 | 2015-09 | 2017-04 | 2017-04 |
| NCT02459899 | Dose-ranging Study in Patients With Type 1 Diabetes Mellitus | COMPLETED | PHASE2 | 2015-07 | 2016-08 | 2016-08 |
| NCT02494609 | Oral Contraceptive DDI Study | UNKNOWN | PHASE1 | 2015-07 | | 2015-11 |
| NCT02471274 | PK Study of Sotagliflozin in Subjects With Hepatic Impairment | COMPLETED | PHASE1 | 2015-06 | | 2015-12 |
| NCT02421510 | Efficacy, Safety, and Tolerability Study of Sotagliflozin as Adjunct Therapy in Adult Patients With Type 1 Diabetes Mellitus Who Have Inadequate Glycemic Control With Insulin Therapy | COMPLETED | PHASE3 | 2015-05 | 2017-06-23 | 2016-11 |
| NCT02383940 | Efficacy and Safety of Sotagliflozin in Young Adult Patients With Type 1 Diabetes Mellitus and Elevated Hemoglobin A1C | COMPLETED | PHASE2 | 2015-04 | 2016-09 | 2016-09 |
| NCT02384941 | Efficacy, Safety, and Tolerability Study of Sotagliflozin as Adjunct Therapy in Adult Patients With Type 1 Diabetes Mellitus Who Have Inadequate Glycemic Control With Insulin Therapy | COMPLETED | PHASE3 | 2015-03 | 2017-02 | 2016-09 |
| NCT02373046 | Bioequivalence Study Between 400 mg LX4211 Tablets and 2 X 200 mg LX4211 Tablets | COMPLETED | PHASE1 | 2015-02 | | 2015-04 |
| NCT02300363 | DDI Study With Multiple-dose LX4211 and Single Dose Rosuvastatin | COMPLETED | PHASE1 | 2014-10 | 2014-11 | 2014-11 |
| NCT02300350 | DDI Study With Multiple-dose LX4211 and Single Dose Digoxin | COMPLETED | PHASE1 | 2014-10 | 2014-12 | 2014-12 |
| NCT02195635 | Phase 1, Open-label, Drug-drug Interaction Study With Octreotide Acetate Injection and Telotristat Etiprate in Healthy Subjects | COMPLETED | PHASE1 | 2014-07 | | 2014-10 |
| NCT02157558 | An Open-Label Drug-Drug Interaction Study of Telotristat Etiprate and Fexofenadine in Healthy Subjects | COMPLETED | PHASE1 | 2014-07 | | 2014-08 |
| NCT02157584 | An Open-Label Food Effect Study of Telotristat Etiprate | COMPLETED | PHASE1 | 2014-06 | | 2014-07 |
| NCT02155205 | A Thorough QT Study of Telotristat Etiprate | COMPLETED | PHASE1 | 2014-05 | | 2014-08 |
| NCT02147808 | A Open-Label Drug-Drug Interaction Study of Telotristat Etiprate and Midazolam in Healthy Subjects | COMPLETED | PHASE1 | 2014-05 | | 2014-08 |
| NCT02063659 | Telotristat Etiprate for Carcinoid Syndrome Therapy | COMPLETED | PHASE3 | 2014-03-11 | 2016-03-29 | 2016-03-29 |
| NCT02026063 | Telotristat Etiprate - Expanded Treatment for Patients With Carcinoid Syndrome Symptoms | COMPLETED | PHASE3 | 2014-01-14 | 2018-09-12 | 2018-09-12 |
| NCT01916850 | Study to Determine the Safety, Tolerability and Pharmacokinetics Following Multiple Doses of LX4211 in Healthy Subjects | COMPLETED | PHASE1 | 2013-08 | | 2013-10 |
| NCT01916863 | Study to Evaluate the Effect of Single Doses of LX4211 and Canagliflozin on Intestinal Glucose Absorption in Healthy Adult Subjects | COMPLETED | PHASE1 | 2013-08 | | 2013-10 |
| NCT01932528 | An Open-label Study to Evaluate the Absorption, Metabolism, and Excretion of [14C]-Telotristat Etiprate in Males | COMPLETED | PHASE1 | 2013-08 | | 2013-09 |
| NCT01913002 | Study to Define the Electrocardiogram Effects of a Single Dose of LX4211 in Healthy Subjects | COMPLETED | PHASE1 | 2013-07 | | 2013-10 |
| NCT01818232 | Study to Determine the Absorption, Metabolism, and Excretion of [14C]LX4211 in Healthy Male Subjects | COMPLETED | PHASE1 | 2013-03 | 2013-05 | 2013-05 |
| NCT01742208 | Safety and Efficacy of Sotagliflozin (LX4211) in Patients With Inadequately Controlled Type 1 Diabetes Mellitus | COMPLETED | PHASE2 | 2013-02 | 2014-01 | 2014-01 |
| NCT01677910 | TELESTAR (Telotristat Etiprate for Somatostatin Analogue Not Adequately Controlled Carcinoid Syndrome) | COMPLETED | PHASE3 | 2013-01-08 | 2016-03-21 | 2016-03-21 |
| NCT01528111 | Study to Evaluate the Safety, Tolerability, and Efficacy of LX7101 in Subjects With Primary Open-angle Glaucoma or Ocular Hypertension | COMPLETED | PHASE1, PHASE2 | 2012-03 | 2012-06 | 2012-06 |
| NCT01555008 | Study to Evaluate the Pharmacodynamic and Pharmacokinetic Effects of LX4211 in Subjects With Type 2 Diabetes and Renal Impairment | COMPLETED | PHASE1 | 2012-03 | | 2013-08 |
| NCT01494233 | A Multi-Center Trial to Determine the Safety and Efficacy of LX1033 in Subjects With Diarrhea-Predominant Irritable Bowel Syndrome | COMPLETED | PHASE2 | 2012-02 | | 2013-09 |
| NCT01456052 | A Study to Evaluate Safety and Efficacy of Telotristat Etiprate (LX1606) in Participants With Acute, Mild to Moderate Ulcerative Colitis | COMPLETED | PHASE2 | 2012-01-30 | 2013-09-03 | 2013-09-03 |
| NCT01441232 | A Study to Evaluate the Pharmacodynamic Effects of Single-Dose Co-Administration of LX4211 With Januvia® in Type 2 Diabetics | COMPLETED | PHASE1 | 2011-10 | | 2011-11 |
| NCT01417052 | A Study to Determine the Safety and Efficacy of LX3305 in Subjects With Active Rheumatoid Arthritis | COMPLETED | PHASE1 | 2011-09 | 2012-06 | 2012-06 |
| NCT01411800 | An Open-Label Study of Two Formulations of LX1033 in Healthy Human Subjects | COMPLETED | PHASE1 | 2011-08 | 2012-05 | 2011-10 |
| NCT01376557 | Safety and Efficacy of LX4211 With Metformin in Type 2 Diabetes Patients With Inadequate Glycemic Control on Metformin | COMPLETED | PHASE2 | 2011-06 | 2012-05 | 2012-05 |
| NCT01334242 | A Study to Determine the Pharmacodynamics of LX4211 Relative to Meals in Healthy Subjects | COMPLETED | PHASE1 | 2011-03 | | 2011-04 |
| NCT01292993 | A Study to Evaluate the Interaction of LX4211 and Metformin in Healthy Subjects | COMPLETED | PHASE1 | 2011-02 | | 2011-03 |
| NCT01188863 | Study of Two Oral Formulations of LX4211 in Patients With Type 2 Diabetes Mellitus | COMPLETED | PHASE1 | 2010-09 | | 2010-10 |
| NCT01104415 | Study of Telotristat Etiprate (LX1606) in Participants With Symptomatic Carcinoid Syndrome | COMPLETED | PHASE2 | 2010-06-15 | 2014-02-12 | 2014-02-12 |
| NCT00962065 | Study of LX4211 in Subjects With Type 2 Diabetes Mellitus | COMPLETED | PHASE2 | 2009-08 | | 2009-12 |
| NCT00903383 | Study of LX3305 in Subjects With Active Rheumatoid Arthritis on Stable Methotrexate | COMPLETED | PHASE2 | 2009-07 | | 2010-09 |
| NCT00853047 | Study of Telotristat Etiprate (LX1606) in Participants With Symptomatic Carcinoid Syndrome Not Managed by Stable-Dose Octreotide Therapy | COMPLETED | PHASE2 | 2009-03 | 2014-06 | 2014-06 |
| NCT00847886 | Study of LX3305 and Methotrexate in Subjects With Stable Rheumatoid Arthritis | COMPLETED | PHASE1 | 2009-02 | 2009-03 | 2009-03 |
| NCT00813098 | Study of LX1031 in Subjects With Non-Constipating Irritable Bowel Syndrome | COMPLETED | PHASE2 | 2008-12 | 2010-08 | 2009-07 |
| NCT00691808 | Study of LX6171 in Elderly Volunteers With Age Associated Memory Impairment | COMPLETED | PHASE2 | 2008-02 | | 2008-10 |