| NCT06467084 | Open-Label Safety, PK, and Efficacy Trial of Sebetralstat (KVD900) in Pediatric Patients (Ages 2-11) With HAE Type I or II | RECRUITING | PHASE3 | 2024-06-24 | 2027-08-31 | 2027-08-31 |
| NCT05511922 | PK Subtrial in Adolescent Patients With HAE Type I or II Participating in the KVD900-302 Trial | ACTIVE_NOT_RECRUITING | PHASE3 | 2022-10-24 | 2026-06-30 | 2026-06-30 |
| NCT05505916 | An Open-label Extension Trial to Evaluate the Long-term Safety of KVD900 (Sebetralstat) for On-Demand Treatment of Angioedema Attacks in Adolescent and Adult Patients With Hereditary Angioedema (HAE) | ACTIVE_NOT_RECRUITING | PHASE3 | 2022-10-24 | 2026-06-30 | 2026-06-30 |
| NCT05259917 | A Phase III, Crossover Trial Evaluating the Efficacy and Safety of KVD900 (Sebetralstat) for On-Demand Treatment of Angioedema Attacks in Adolescent and Adult Patients With Hereditary Angioedema (HAE) | COMPLETED | PHASE3 | 2022-02-22 | 2023-12-31 | 2023-12-31 |
| NCT05055258 | A Trial to Evaluate the Efficacy and Safety of Different Doses of KVD824 for Prophylactic Treatment of HAE Type I or II | TERMINATED | PHASE2 | 2021-09-27 | 2022-10-27 | 2022-10-27 |
| NCT05118958 | Phase 1 Crossover Study in Healthy Subjects to Evaluate the PK Profile of KVD824 Following Single and Multiple Doses of Modified Release (MR) Formulations | COMPLETED | PHASE1 | 2020-05-19 | 2020-12-01 | 2020-12-01 |
| NCT04208412 | A Phase II, Cross-over Clinical Trial Evaluating the Efficacy and Safety of KVD900 (Sebetralstat) in the On-demand Treatment of Angioedema Attacks in Adult Subjects With Hereditary Angioedema Type I or II | COMPLETED | PHASE2 | 2019-07-02 | 2020-12-08 | 2020-12-08 |
| NCT05178355 | A Single and Multiple Doses Safety, Tolerability, Pharmacokinetics and Food Effect Study of KVD824 in Healthy Volunteers | COMPLETED | PHASE1 | 2019-02-12 | 2019-06-21 | 2019-06-21 |
| NCT03466099 | Study of the Intravitreal Plasma Kallikrein Inhibitor, KVD001, in Subjects With Center-involving Diabetic Macular Edema (ciDME) | COMPLETED | PHASE2 | 2018-02-16 | 2019-10-10 | 2019-10-10 |
| NCT04349800 | A Single Dose Safety, Tolerability, Pharmacokinetic and Food Effect Study of KVD900 (Sebetralstat) in Healthy Volunteers | COMPLETED | PHASE1 | 2018-01-04 | 2018-09-10 | 2018-09-10 |
| NCT02193113 | A Phase I Single Ascending Dose Study of the Intravitreal Plasma Kallikrein Inhibitor KVD001 in Subjects With DME | COMPLETED | PHASE1 | 2014-07-18 | 2015-06-04 | 2015-06-04 |