| NCT06689085 | 52 Week Study of Safety, PK, & Efficacy of XYOSTED® for Testosterone Replacement in Male Adolescents With Hypogonadism | RECRUITING | PHASE3 | 2025-02-05 | 2027-12 | 2027-10 |
| NCT03267940 | Study of PEGPH20 With Cisplatin (CIS) and Gemcitabine (GEM); PEGPH20 With Atezolizumab (ATEZO), CIS, and GEM; and CIS and GEM Alone in Participants With Previously Untreated, Unresectable, Locally Advanced, or Metastatic Intrahepatic and Extrahepatic Cholangiocarcinoma and Gallbladder Adenocarcinoma | TERMINATED | PHASE1 | 2017-10-02 | 2019-11-11 | 2019-11-11 |
| NCT02715804 | A Study of PEGylated Recombinant Human Hyaluronidase in Combination With Nab-Paclitaxel Plus Gemcitabine Compared With Placebo Plus Nab-Paclitaxel and Gemcitabine in Participants With Hyaluronan-High Stage IV Previously Untreated Pancreatic Ductal Adenocarcinoma | TERMINATED | PHASE3 | 2016-03-14 | 2019-11-04 | 2019-11-04 |
| NCT02563548 | A Study of PEGylated Recombinant Human Hyaluronidase (PEGPH20) With Pembrolizumab in Participants With Selected Hyaluronan High Solid Tumors | COMPLETED | PHASE1 | 2015-10-22 | 2019-03-26 | 2019-03-26 |
| NCT02346370 | A Phase 1b Study of PEGylated Recombinant Human Hyaluronidase (PEGPH20) Combined With Docetaxel in Subjects With Recurrent Previously Treated Locally Advanced or Metastatic NSCLC | TERMINATED | PHASE1 | 2015-02-10 | 2016-11-14 | 2016-08-09 |
| NCT03662334 | A Study of Continuous Subcutaneous Insulin Infusion (CSII) Pump Function in Subjects With Type 1 Diabetes With Recombinant Human Hyaluronidase (rHuPH20) | COMPLETED | PHASE4 | 2013-10-03 | 2014-02-27 | 2014-02-27 |
| NCT01839487 | PEGPH20 Plus Nab-Paclitaxel Plus Gemcitabine Compared With Nab-Paclitaxel Plus Gemcitabine in Participants With Stage IV Untreated Pancreatic Cancer | COMPLETED | PHASE2 | 2013-05-14 | 2018-09-26 | 2018-05-01 |
| NCT01848990 | CONSISTENT 1: Metabolic and Safety Outcomes of Hylenex Recombinant (Hyaluronidase Human Injection) Preadministered at CSII Infusion Site in Participants With Type 1 Diabetes Mellitus (T1DM) | COMPLETED | PHASE4 | 2013-03 | 2014-09 | 2014-02 |
| NCT01572012 | Phase 1 Safety, Tolerability and PK Study of Ondansetron and Hylenex Recombinant in Healthy Volunteers | COMPLETED | PHASE1 | 2012-02 | 2013-11 | 2013-11 |
| NCT01526733 | Randomized, Double Blind, 2 Way Crossover Study of CSII With, Versus Without, Pretreatment With Human Hyaluronidase | COMPLETED | PHASE4 | 2011-12 | 2013-09 | 2012-08 |
| NCT01453153 | Study of Gemcitabine + PEGPH20 vs Gemcitabine Alone in Stage IV Previously Untreated Pancreatic Cancer | COMPLETED | PHASE1, PHASE2 | 2011-09 | 2015-05 | 2014-02 |
| NCT01275131 | Randomized, Double-blind, Crossover, Pharmacokinetic (PK) and Glucodynamic (GD) Study of Continuous Subcutaneous Insulin Infusion (CSII) in Participants With Type 1 Diabetes Mellitus (T1DM) | COMPLETED | PHASE1 | 2011-01 | 2011-12 | 2011-12 |
| NCT01194245 | Safety/Efficacy Study of Subcutaneously Injected Prandial Insulins Compared to Insulin Lispro Alone in Participants With Type 1 Diabetes Mellitus | COMPLETED | PHASE2 | 2010-08 | 2011-08 | 2011-08 |
| NCT01194258 | Safety/Efficacy Study of Subcutaneously Injected Prandial Insulins Compared to Insulin Lispro Alone in Patients With Type 2 Diabetes Mellitus | COMPLETED | PHASE2 | 2010-08 | 2011-08 | 2011-08 |
| NCT01170897 | Study of PEGPH20 With Initial Dexamethasone Premedication Given Intravenously to Patients With Advanced Solid Tumors | COMPLETED | PHASE1 | 2010-07 | 2014-01 | 2013-10 |
| NCT00979875 | A Pharmacokinetic and Glucodynamic Study of Subcutaneously Administered Insulin Analogs With rHuPH20 Compared to Insulin Analogs Alone | COMPLETED | PHASE1 | 2009-09 | 2010-05 | 2010-02 |
| NCT00916357 | Liquid Meal Study With Insulin Lispro With/Without Recombinant Human Hyaluronidase PH20 (rHuPH20) and Regular Human Insulin With rHuPH20 to Compare Pharmacokinetics, Postprandial Glycemic Response, and Optimal Insulin Dose in Participants With Type 2 Diabetes Mellitus (T2DM) | COMPLETED | PHASE2 | 2009-07 | 2009-11 | 2009-11 |
| NCT00928447 | Study of the Intradermal Injection of rHuPH20 or Placebo in Participants With Nickel Allergic Contact Dermatitis | COMPLETED | PHASE2 | 2009-06-23 | 2009-09-13 | 2009-09-13 |
| NCT00883558 | Safety Study of Subcutaneously-Injected Prandial INSULIN-PH20 NP Compared to Insulin Lispro Injection in Participants With Type 1 Diabetes Mellitus | COMPLETED | PHASE2 | 2009-05 | 2010-04 | 2010-02 |
| NCT00862849 | Pharmacokinetic and Glucodynamic Crossover Study of Subcutaneously (SC) Administered Insulin Lispro + Recombinant Human Hyaluronidase (rHuPH20) and Regular Human Insulin + rHuPH20 Compared to Insulin Lispro Alone | COMPLETED | PHASE1 | 2009-03 | 2009-08 | 2009-06 |
| NCT00834704 | Safety Study of PEGPH20 Given to Patients With Advanced Solid Tumors | COMPLETED | PHASE1 | 2009-02 | 2012-11 | 2012-06 |
| NCT00807963 | Pharmacokinetic, Safety and Tolerability Study of SC Administered Bisphosphonate With rHuPH20 vs Bisphosphonate Alone | COMPLETED | PHASE1 | 2008-12 | 2009-09-21 | 2009-09-21 |
| NCT00803972 | Dose-Ranging, Pharmacokinetic (PK), Glucodynamic (GD), Safety and Tolerability Study of Subcutaneously (SC) Administered Humulin R and Humalog With or Without rHuPH20 | COMPLETED | PHASE1 | 2008-11 | 2009-08-28 | 2009-08-28 |
| NCT00774800 | Phase II Pharmacokinetics Study of Humalog and Humulin-R With and Without rHuPH20 in Type 1 Diabetes Mellitus | COMPLETED | PHASE2 | 2008-10 | 2009-03 | 2009-03 |
| NCT00773175 | Subcutaneous Rehydration Compared to Intravenous Rehydration | COMPLETED | PHASE4 | 2008-10 | 2009-12 | 2009-11 |
| NCT00782587 | Study of Immediate Post-Operative Intravesical Instillation of Chemophase® in Patients With Superficial Bladder Cancer | COMPLETED | PHASE1 | 2008-10 | 2009-08 | 2009-03 |
| NCT00705536 | Pharmacokinetic (PK), Pharmacodynamic (PD), and Safety Study of Subcutaneously Administered Humalog® With and Without Recombinant Human Hyaluronidase (rHuPH20)and Humulin-R® With and Without rHuPH20 | COMPLETED | PHASE1 | 2007-12 | 2008-02 | 2008-02 |
| NCT00656370 | Study of Subcutaneous Hydration Enabled by Human Recombinant Hyaluronidase (Hylenex) | COMPLETED | PHASE4 | 2007-12 | 2008-01-30 | 2008-01-30 |
| NCT00435604 | A Study of the Subcutaneous Injection of a Viscous Antibody Solution With Recombinant Human Hyaluronidase | COMPLETED | PHASE1 | 2007-02 | 2007-05 | |
| NCT00369187 | Study of a Large Protein Molecule Administered With Escalating Doses of Recombinant Human Hyaluronidase | COMPLETED | PHASE4 | 2006-07 | 2006-10 | |
| NCT00318643 | Safety Study of Recombinant Human Hyaluronidase (Chemophase) in Combination With Mitomycin in Participants With Superficial Bladder Cancer | COMPLETED | PHASE1, PHASE2 | 2006-03-30 | 2009-08-11 | 2009-08-11 |
| NCT00593281 | INFUSE Morphine Study | COMPLETED | PHASE3 | 2006-01 | 2006-10 | 2006-10 |
| NCT00311519 | A Phase IIIB Dose Comparison Study of Subcutaneous Hydration With and Without Human Recombinant Hyaluronidase (HYLENEX) in Volunteer Subjects | COMPLETED | PHASE4 | 2005-11 | 2006-01 | |