| NCT06793371 | AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF | RECRUITING | PHASE2 | 2025-02-06 | 2026-09 | 2026-09 |
| NCT06736574 | Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction | RECRUITING | PHASE3 | 2024-12-19 | 2027-12 | 2027-09 |
| NCT06412666 | A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM). | RECRUITING | PHASE2, PHASE3 | 2024-05-29 | 2030-01 | 2030-01 |
| NCT06081894 | Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic nHCM | RECRUITING | PHASE3 | 2023-08-30 | 2026-09 | 2026-06 |
| NCT05767346 | Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol Succinate in Adults With Symptomatic oHCM | COMPLETED | PHASE3 | 2023-06-20 | 2025-03-28 | 2025-02-28 |
| NCT05924815 | Study to Evaluate the Effect of Aficamten Administration on QT/QTc Interval | COMPLETED | PHASE1 | 2023-05-15 | 2023-11-14 | 2023-11-14 |
| NCT05877053 | A Single and Multiple Ascending Dose Study of CK-4021586 in Healthy Adult Participants | COMPLETED | PHASE1 | 2023-05-09 | 2024-11-20 | 2024-11-20 |
| NCT05662215 | A Single and Multiple Ascending Dose Study of CK-3828136 in Healthy Adult Participants | TERMINATED | PHASE1 | 2022-12-06 | 2023-08-08 | 2023-08-08 |
| NCT05442775 | A Phase 3, Open-Label Extension of COURAGE-ALS (CY 5031) | TERMINATED | PHASE3 | 2022-08-04 | 2023-06-07 | 2023-06-07 |
| NCT05186818 | Aficamten vs Placebo in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy (SEQUOIA-HCM) | COMPLETED | PHASE3 | 2022-02-01 | 2023-12-18 | 2023-11-10 |
| NCT04944784 | A Study to Evaluate the Efficacy and Safety of Reldesemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS) | TERMINATED | PHASE3 | 2021-08-16 | 2023-07-18 | 2023-07-18 |
| NCT04848506 | Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM | ENROLLING_BY_INVITATION | PHASE2, PHASE3 | 2021-05-06 | 2028-03 | 2028-03 |
| NCT04464525 | Omecamtiv Mecarbil Post-trial Access Study | WITHDRAWN | PHASE3 | 2020-12-18 | 2026-11-27 | 2026-11-27 |
| NCT04219826 | Dose-finding Study to Evaluate the Safety, Tolerability, PK, and PD of CK-3773274 in Adults With HCM | COMPLETED | PHASE2 | 2020-01-10 | 2023-02-28 | 2023-02-28 |
| NCT04175808 | Study to Assess the Effect of Omecamtiv Mecarbil (OM) on QT/QTc Intervals in Healthy Adults | COMPLETED | PHASE1 | 2019-11-14 | 2020-03-04 | 2020-03-04 |
| NCT03759392 | Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart Failure | COMPLETED | PHASE3 | 2019-04-09 | 2022-01-06 | 2021-11-08 |
| NCT03767855 | A Single and Multiple Ascending Dose Study of CK-3773274 in Healthy Adult Subjects | COMPLETED | PHASE1 | 2018-12-04 | 2020-01-03 | 2020-01-03 |
| NCT03160898 | A Study to Evaluate Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS) | COMPLETED | PHASE2 | 2017-07-24 | 2019-03-07 | 2019-03-07 |
| NCT02929329 | Registrational Study With Omecamtiv Mecarbil (AMG 423) to Treat Chronic Heart Failure With Reduced Ejection Fraction | COMPLETED | PHASE3 | 2017-01-06 | 2020-09-14 | 2020-09-14 |
| NCT02936635 | A Study for Patients Who Completed VITALITY-ALS (CY 4031) | COMPLETED | PHASE3 | 2016-10-17 | 2018-10-26 | 2018-10-26 |
| NCT02695420 | Safety, PK, and Efficacy of Omecamtiv Mecarbil in Japanese Subjects With Heart Failure With Reduced Ejection Fraction | COMPLETED | PHASE2 | 2016-04-14 | 2017-05-08 | 2017-04-06 |
| NCT02644668 | A Study of CK-2127107 in Patients With Spinal Muscular Atrophy | COMPLETED | PHASE2 | 2016-01-14 | 2018-05-31 | 2018-05-31 |
| NCT02601001 | Pharmacokinetics and Safety Study of Omecamtiv Mecarbil in Healthy Japanese Adults | COMPLETED | PHASE1 | 2015-11-13 | 2016-01-06 | 2016-01-06 |
| NCT02496767 | Ventilatory Investigation of Tirasemtiv and Assessment of Longitudinal Indices After Treatment for a Year | COMPLETED | PHASE3 | 2015-09-03 | 2017-09-27 | 2017-03-09 |
| NCT01786512 | COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure | COMPLETED | PHASE2 | 2013-02-26 | 2015-08-19 | 2015-07-22 |
| NCT01737866 | Pharmacokinetics Study of AMG 423 in Healthy Subjects and Subjects With Various Degrees of Renal Insufficiency | COMPLETED | PHASE1 | 2012-11 | 2013-05 | 2013-01 |
| NCT01709149 | Study of Safety, Tolerability & Efficacy of CK-2017357 in Amyotrophic Lateral Sclerosis (ALS) | COMPLETED | PHASE2 | 2012-10 | 2014-03 | 2014-03 |
| NCT01486849 | Dose Titration Study to Test Safety and Effects of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS) | COMPLETED | PHASE2 | 2011-11 | 2012-03 | 2012-03 |
| NCT01378676 | A Study to Evaluate the Effects of Multiple Doses of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS) | COMPLETED | PHASE2 | 2011-06 | 2012-03 | 2012-03 |
| NCT01300013 | Study to Evaluate the Safety and Efficacy of IV Infusion Treatment With Omecamtiv Mecarbil in Subjects With Left Ventricular Systolic Dysfunction Hospitalized for Acute Heart Failure (ATOMIC-AHF) | COMPLETED | PHASE2 | 2011-04 | 2013-09 | 2013-04 |
| NCT01268280 | Pharmacodynamic Study of CK-2017357 in Patients With Generalized Myasthenia Gravis | TERMINATED | PHASE2 | 2010-12 | 2012-10 | 2012-10 |
| NCT01077167 | Pharmacokinetic Study of Omecamtiv Mecarbil in Heart Failure Patients | WITHDRAWN | PHASE2 | 2010-07 | 2011-05 | 2011-05 |
| NCT01131013 | A Study of CK-2017357 in Patients With Peripheral Artery Disease and Symptomatic Claudication | COMPLETED | PHASE2 | 2010-05 | 2011-03 | 2011-03 |
| NCT01089010 | A Study of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS) | COMPLETED | PHASE2 | 2010-03 | 2010-11 | 2010-11 |
| NCT00941681 | Pharmacokinetics of Oral CK-1827452 in Patients With Stable Heart Failure | COMPLETED | PHASE2 | 2009-04 | 2009-10 | 2009-10 |
| NCT00748579 | Phase II Study of the Effect of CK-1827452 Injection on Myocardial Efficiency | TERMINATED | PHASE2 | 2008-09 | 2009-07 | 2008-11 |
| NCT00682565 | PK and Tolerability of IV and Oral CK-1827452 in Patients With Ischemic Cardiomyopathy and Angina | COMPLETED | PHASE2 | 2008-04 | 2009-03 | 2008-11 |
| NCT00607841 | A Study of Ispinesib in Metastatic Breast Cancer | TERMINATED | PHASE1 | 2007-12 | 2009-11 | 2009-11 |
| NCT00624442 | A Study of CK-1827452 Infusion in Stable Heart Failure | COMPLETED | PHASE2 | 2007-04 | 2009-02 | 2009-02 |
| NCT00343564 | A Study of SB-743921 in Non-Hodgkin Lymphoma and Hodgkin Lymphoma | COMPLETED | PHASE1, PHASE2 | 2006-04 | 2010-07 | 2010-07 |
| NCT01380223 | A Pharmacokinetic and Pharmacodynamic Study of Omecamtiv Mecarbil in Healthy Volunteers | COMPLETED | PHASE1 | 2005-08 | 2006-04 | 2006-04 |