| NCT07213960 | A Sequential Phase 2/3 Study of APL2 in Patients With Focal Segmental Glomerulosclerosis | NOT_YET_RECRUITING | PHASE2, PHASE3 | 2025-12 | 2029-12 | 2029-10 |
| NCT07214740 | Study to Evaluate a Pegcetacoplan (Syfovre®) Prefilled Syringe | NOT_YET_RECRUITING | PHASE3 | 2025-10 | 2026-01 | 2026-01 |
| NCT07020832 | A Phase 3 Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults at High Risk of Delayed Graft Function (DGF) Following Kidney Allograft Transplantation | NOT_YET_RECRUITING | PHASE3 | 2025-09 | 2028-08 | 2027-08 |
| NCT05809531 | An Open-Label, Nonrandomized, Multicenter Extension Study to Evaluate the Long-term Safety and Efficacy of Pegcetacoplan in Participants With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis | ACTIVE_NOT_RECRUITING | PHASE3 | 2023-05-29 | 2027-07 | 2027-07 |
| NCT05067127 | Phase III Study Assessing the Efficacy and Safety of Pegcetacoplan in Patients With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis | COMPLETED | PHASE3 | 2021-11-12 | 2025-01-14 | 2024-06-26 |
| NCT04572854 | Study Assessing the Safety and Efficacy of Pegcetacoplan in Post-Transplant Recurrence of C3G or IC-MPGN | ACTIVE_NOT_RECRUITING | PHASE2 | 2021-09-07 | 2026-01 | 2023-02-27 |
| NCT04770545 | An Extension Study to Evaluate the Long-term Safety and Efficacy of Pegcetacoplan (APL-2) in Subjects With Geographic Atrophy Secondary to AMD | ACTIVE_NOT_RECRUITING | PHASE3 | 2021-03-04 | 2026-09 | 2025-09 |
| NCT04901936 | A Study of Pegcetacoplan in Pediatric Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) | RECRUITING | PHASE2 | 2021-02-04 | 2028-12 | 2028-12 |
| NCT04579666 | MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Sclerosis (ALS) | TERMINATED | PHASE2 | 2020-09-30 | 2023-07-13 | 2023-03-31 |
| NCT04402060 | A Study of APL-9 in Adults With Mild to Moderate ARDS Due to COVID-19 | COMPLETED | PHASE1, PHASE2 | 2020-05-28 | 2021-02-13 | 2021-02-13 |
| NCT04085601 | A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Patients With PNH | COMPLETED | PHASE3 | 2019-08-27 | 2021-06-23 | 2021-06-23 |
| NCT03777332 | Study to Evaluate the Safety of Intravitreal APL-2 in Patients Diagnosed With Geographic Atrophy | COMPLETED | PHASE1 | 2018-11-05 | 2021-04-01 | 2021-04-01 |
| NCT03525613 | A Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration | COMPLETED | PHASE3 | 2018-08-31 | 2022-06-28 | 2021-06-28 |
| NCT03525600 | Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration | COMPLETED | PHASE3 | 2018-08-31 | 2022-06-20 | 2021-06-21 |
| NCT03531255 | Pegcetacoplan Long Term Safety and Efficacy Extension Study | ACTIVE_NOT_RECRUITING | PHASE3 | 2018-08-27 | 2025-06 | 2025-06 |
| NCT03593200 | A Phase IIa Study to Assess the Safety, Efficacy, and Pharmacokinetics of Subcutaneously Administered Pegcetacoplan (APL-2) in Subjects With PNH | COMPLETED | PHASE2 | 2018-08-16 | 2019-10-22 | 2019-10-22 |
| NCT03500549 | Study to Evaluate the Efficacy and Safety of APL-2 in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) | COMPLETED | PHASE3 | 2018-06-14 | 2020-08-13 | 2019-11-14 |
| NCT03453619 | Phase II Study Assessing Safety and Efficacy of APL-2 in Glomerulopathies | COMPLETED | PHASE2 | 2018-02-26 | 2023-08-26 | 2020-04-16 |
| NCT03465709 | Pegcetacoplan (APL-2) in Neovascular AMD | TERMINATED | PHASE1, PHASE2 | 2018-02-14 | 2019-04-05 | 2019-04-05 |
| NCT03226678 | Study to Assess the Safety, Tolerability, Efficacy and PK of APL-2 in Patients With Warm Type Autoimmune Hemolytic Anemia (wAIHA) or Cold Agglutinin Disease (CAD) | COMPLETED | PHASE2 | 2017-08-31 | 2022-09-12 | 2022-09-12 |
| NCT02588833 | Pilot Study to Assess Safety, Preliminary Efficacy and Pharmacokinetics of S.C. Pegcetacoplan (APL-2) in PNH Subjects. | COMPLETED | PHASE1 | 2015-12-01 | 2019-08-26 | 2019-08-26 |
| NCT02503332 | Study of Pegcetacoplan (APL-2) Therapy in Patients With Geographic Atrophy | COMPLETED | PHASE2 | 2015-09-24 | 2018-01-17 | 2017-07-14 |
| NCT02264639 | A Phase I Study to Assess the Safety of Pegcetacoplan (APL-2) as an Add-On to Standard of Care in Subjects With PNH | COMPLETED | PHASE1 | 2015-02-23 | 2018-10-22 | 2018-10-22 |
| NCT02461771 | Assessment of Safety, Tolerability and Pharmacokinetics of Intravitreal Pegcetacoplan (APL-2) for Patients With Wet AMD | COMPLETED | PHASE1 | 2015-01-28 | 2016-03-08 | 2016-03-08 |