| NCT06901505 | To Evaluate the Efficacy of Three Times Weekly (TIW) Vadadustat Compared to Standard of Care ESA in Patients With Anemia of CKD Receiving In-Center Hemodialysis | RECRUITING | PHASE3 | 2025-07-24 | 2026-06 | 2026-06 |
| NCT05082571 | Study to Evaluate the Safety and Efficacy of Oral Vadadustat in Pediatric Participants With Anemia of Chronic Kidney Disease | WITHDRAWN | PHASE3 | 2025-01 | 2026-10 | 2026-07 |
| NCT05082584 | Study to Evaluate the Safety and Efficacy of Oral Vadadustat in Pediatric Participants With Anemia of Chronic Kidney Disease Naive to Erythropoiesis-Stimulating Agents | WITHDRAWN | PHASE3 | 2025-01 | 2026-10 | 2026-07 |
| NCT04707768 | Study Evaluating the Efficacy and Safety of Dose Conversion From a Long-acting Erythropoiesis-stimulating Agent (Mircera®) to Three Times Weekly Oral Vadadustat for the Maintenance Treatment of Anemia in Hemodialysis Subjects | COMPLETED | PHASE3 | 2021-06-18 | 2023-01-30 | 2023-01-06 |
| NCT04299633 | Study in Healthy Adult Subjects to Assess the Effect of Phosphate Binders on the Pharmacokinetics of a Single Dose of Vadadustat | COMPLETED | PHASE1 | 2020-06-15 | 2020-09-28 | 2020-08-02 |
| NCT04313153 | Trial Evaluating the Efficacy and Safety of Oral Vadadustat Once Daily (QD) and Three Times Weekly (TIW) for the Maintenance Treatment of Anemia in Hemodialysis Subjects Converting From Erythropoiesis-Stimulating Agents (ESAs) | COMPLETED | PHASE3 | 2020-05-27 | 2022-06-22 | 2021-11-26 |
| NCT03992066 | Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Vadadustat in Hemodialysis Subjects With Anemia Associated With Chronic Kidney Disease | COMPLETED | PHASE1 | 2019-05-28 | 2020-07-15 | 2020-05-05 |
| NCT03799627 | Study of Vadadustat in Hemodialysis Participants With Anemia Switching From Epoetin Alfa | COMPLETED | PHASE2 | 2019-01-31 | 2020-07-15 | 2020-06-05 |
| NCT03789032 | Study to Evaluate the Effect of Rabeprazole on the Pharmacokinetics of Vadadustat | COMPLETED | PHASE1 | 2018-10-03 | 2018-11-19 | 2018-11-09 |
| NCT03657290 | A Study in Evaluating Bioequivalence of Test and Reference Vadadustat 450 MG and 150 MG Tablets and to Determine Food Effect on the 450 MG Tablet | COMPLETED | PHASE1 | 2018-08-03 | 2018-10-16 | 2018-10-16 |
| NCT03801759 | Drug-Drug Interaction Study of Vadadustat With Digoxin, Adefovir and Furosemide | COMPLETED | PHASE1 | 2018-07-20 | 2018-09-30 | 2018-09-30 |
| NCT03801746 | Drug-Drug Interaction Study of Vadadustat With Cyclosporine, Probenecid and Rifampin | COMPLETED | PHASE1 | 2018-07-20 | 2018-08-15 | 2018-08-15 |
| NCT03801733 | Drug-Drug Interaction Study of Vadadustat With Rosuvastatin, Sulfasalazine, Pravastatin, Atorvastatin and Simvastatin | COMPLETED | PHASE1 | 2018-06-17 | 2018-11-24 | 2018-11-24 |
| NCT03799848 | A Single Dose Study of Oral Vadadustat in Subjects With Normal and Impaired Hepatic Function | COMPLETED | PHASE1 | 2018-06-12 | 2018-10-18 | 2018-10-18 |
| NCT03639155 | A Study in Evaluating Bioequivalence Between Test and Reference Formulations of Vadadustat Tablets in Healthy Adults | COMPLETED | PHASE1 | 2018-04-12 | 2018-05-23 | 2018-05-23 |
| NCT03254485 | A Study of the Effect of IW-1973 on the Exercise Capacity of Patients With Heart Failure With Preserved Ejection Fraction (HFpEF) | COMPLETED | PHASE2 | 2017-11-07 | 2019-08-19 | 2019-08-19 |
| NCT03217591 | A Study to Evaluate the Soluble Guanylate Cyclase (sGC) Stimulator IW-1973 in Diabetic Nephropathy / Diabetic Kidney Disease as Measured by Albuminuria | COMPLETED | PHASE2 | 2017-08-01 | 2019-08-20 | 2019-08-20 |
| NCT03242967 | Study to Evaluate Three Times Per Week (TIW) Oral Dosing of Vadadustat for Anemia in Subjects With Dialysis-Dependent Chronic Kidney Disease (DD-CKD) | WITHDRAWN | PHASE3 | 2017-08 | 2018-02-12 | 2018-02-12 |
| NCT03140722 | Study to Evaluate Vadadustat for Anemia in Subjects With Dialysis-Dependent Chronic Kidney Disease (DD-CKD) Who Are Hyporesponsive to Erythropoiesis Stimulating Agents | TERMINATED | PHASE2 | 2017-05-02 | 2018-03-21 | 2018-03-21 |
| NCT03054350 | Dose-Finding Study of Vadadustat in Japanese Subjects With Anemia Secondary to Dialysis-Dependent Chronic Kidney Disease (DD-CKD) | COMPLETED | PHASE2 | 2016-12 | 2018-01-24 | 2017-10-24 |
| NCT03054337 | Dose-Finding Study of Vadadustat in Japanese Subjects With Anemia Secondary to Non-Dialysis Dependent Chronic Kidney Disease (NDD-CKD) | COMPLETED | PHASE2 | 2016-10 | 2017-08-28 | 2017-07-04 |
| NCT02892149 | Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Participants With Dialysis-dependent Chronic Kidney Disease (DD-CKD) | COMPLETED | PHASE3 | 2016-08 | 2020-03-30 | 2020-01-16 |
| NCT02865850 | Efficacy and Safety Study to Evaluate Vadadustat for the Correction or Maintenance Treatment of Anemia in Participants With Incident Dialysis-dependent Chronic Kidney Disease (DD-CKD) | COMPLETED | PHASE3 | 2016-07 | 2020-03-30 | 2020-01-31 |
| NCT02680574 | Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Participants With Non-dialysis-dependent Chronic Kidney Disease (NDD-CKD) | COMPLETED | PHASE3 | 2016-02 | 2020-07-31 | 2020-06-18 |
| NCT02648347 | Study to Evaluate Vadadustat for the Correction of Anemia in Participants With Non-dialysis-dependent Chronic Kidney Disease | COMPLETED | PHASE3 | 2015-12 | 2020-07-31 | 2020-06-04 |
| NCT02502500 | Effect of AKB-6548 on the Pharmacokinetics of Celecoxib | COMPLETED | PHASE1 | 2015-07 | 2015-09 | 2015-07 |
| NCT02412449 | Relative Bioavailability of Two Formulations of AKB-6548 and the Food Effect of a New Tablet in Healthy Adult Subjects | COMPLETED | PHASE1 | 2015-04 | 2015-04 | 2015-04 |
| NCT02327546 | Effects of Ferrous Sulfate on the Pharmacokinetics of AKB-6548 | COMPLETED | PHASE1 | 2014-12 | 2015-02 | 2014-12 |
| NCT02260193 | 16-Week Repeat Oral Dose Study of AKB-6548 for Anemia in Participants With End Stage Renal Disease (ESRD) Requiring Chronic Hemodialysis | COMPLETED | PHASE2 | 2014-09-10 | 2015-07-22 | 2015-07-22 |
| NCT02062203 | Effect of AKB-6548 on Cardiac Repolarization Intervals in Healthy Volunteers | COMPLETED | PHASE1 | 2014-01 | 2014-04 | 2014-04 |
| NCT01906489 | 20-Week Repeat Oral Dose Study of AKB-6548 in Participants With Chronic Kidney Disease and Anemia | COMPLETED | PHASE2 | 2013-07-23 | 2014-09-03 | 2014-09-03 |
| NCT01381094 | 42-Day Repeat Oral Dose Study of AKB-6548 in Participants With Chronic Kidney Disease and Anemia | COMPLETED | PHASE2 | 2011-06-15 | 2012-02-16 | 2012-02-16 |
| NCT01235936 | Safety and Efficacy Study for AKB-6548 in Participants With Chronic Kidney Disease and Anemia | COMPLETED | PHASE2 | 2010-10-21 | 2011-05 | 2011-04-13 |
| NCT04707573 | Study to Assess the Safety and Pharmacokinetics of AKB-6548 in Participants With Chronic Kidney Disease (CKD), Stages 3 and 4 | COMPLETED | PHASE2 | 2010-07-08 | 2010-09-24 | 2010-09-24 |